2-Amino-5-bromopyridine → N-(5-bromopyridin-2-yl)-N'-(2-fluoro-5-methylphenyl)urea

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[N:17]=[C:18]=[O:19].FC1C=CC=C(N=C=O)C=1>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:18]([NH:17][C:11]2[CH:12]=[C:13]([CH3:16])[CH:14]=[CH:15][C:10]=2[F:9])=[O:19])=[N:3][CH:4]=1

참가 물질

반응물 3

HCID 706222-Amino-5-bromopyridine

HCID 1230643-Fluorophenyl isocyanate

HCID 27333772-Fluoro-5-methylphenyl isocyanate

생성물 1

HCID 66680783N-(5-bromopyridin-2-yl)-N'-(2-fluoro-5-methylphenyl)urea

실험 절차

The desired product was prepared by substituting 2-amino-5-bromopyridine and 1-fluoro-2-isocyanato-4-methylbenzene for Example 15G and 1-fluoro-3-isocyanatobenzene, respectively, in Example 15H. MS (ESI(+)) m/e 324.0 (M+H)+.

출처 및 근거

ORD 기록: ord-562fd293a52f4ba0aee10c7fb26adb85
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08642776B2

반응 노트

불러오는 중…