참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Nitroaniline | HCID 7475 | — |
| 반응물 | 2-Diazonio-1-methoxy-3-oxobut-1-en-1-olate | HCID 54537960 | — |
| 촉매 | Dirhodium tetraacetate | HCID 152122 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 2-[(4-nitrophenyl)amino]-3-oxobutanoate | HCID 70968068 | 98% |
반응 단계
Under an argon atmosphere, to a solution of 4-nitroaniline (3.84 g) in toluene (278 mL) were added methyl 2-diazo-3-oxobutanoate (5.13 g) and rhodium(II) acetate dimer (250 mg), and the mixture was stirred at 120° C. for 1 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=9:1→hexane:ethyl acetate=7:3 (volume ratio)] to give the title compound (4.63 g, yield 98%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08642770B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-1cfa878266b04a4fb7715964e4164ab7 |
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| 출처 메모 | uspto-grants-2014_02 |
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