Nitric Acid → HCID 21432601, 화합물

HRID 2399042노트

반응식

HRID 2399042 반응식
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[N+:15]([O-])([OH:17])=[O:16].[OH-].[NH4+]>>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 14923Ammonium HydroxideHCID 780542-(4'-Chlorobenzyl)pyridine

생성물 1

HCID 21432601HCID 21432601, 화합물

실험 절차

99 G. (0.487 mol) of 2-(p-chlorobenzyl)pyridine was added to 500 ml. of fuming nitric acid cooled to 10 ° while maintaining the temperature at <10° for 2 hours. The resulting mixture was poured into 800 ml. of ice, neutralized with ammonium hydroxide and allowed to stand overnight at room temperature. The resulting solid was collected, washed with water and air dried to give 2-(4-chloro-3-nitrobenzyl)pyridine as off-white prisms, m. 58°-60° C. (aq. ethanol).

후처리

  1. temperaturewhile maintaining the temperature at <10° for 2 hours
  2. additionThe resulting mixture was poured into 800 ml
  3. customThe resulting solid was collected
  4. washwashed with water and air
  5. customdried

출처 및 근거

ORD 기록
ord-d013ac3343f44494b03dee9870966de1
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04026936

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