Potassium Carbonate → N-[2-(2-Pyridylmethylthio)ethyl]thiourea

HRID 2399125노트

반응식

HRID 2399125 반응식
C([NH:9][C:10]([NH:12][CH2:13][CH2:14][S:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][S:15][CH2:14][CH2:13][NH:12][C:10]([NH2:9])=[S:11]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 21432770N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea

생성물 1

HCID 21432760N-[2-(2-Pyridylmethylthio)ethyl]thiourea

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The benzoyl thiourea is added to a solution of potassium carbonate (1.4 g.) in water (80 ml.) at 60°. The solution is maintained at this temperature for one hour, concentrated to low bulk and acidified with hydrochloric acid. Benzoic acid is removed by filtration and the filtrate is basified with potassium carbonate and concentrated under reduced pressure. Following extraction with isopropyl alcohol and concentration, the product is N-[2-(2-pyridylmethylthio)ethyl]thiourea.

후처리

  1. temperatureThe solution is maintained at this temperature for one hour
  2. concentrationconcentrated to low bulk
  3. customBenzoic acid is removed by filtration
  4. concentrationconcentrated under reduced pressure
  5. extractionextraction
  6. concentrationwith isopropyl alcohol and concentration

출처 및 근거

ORD 기록
ord-fa2c0217bf0a41358db4f7b440311365
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04027026

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