Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
o-CRESYL GLYCIDYL ETHER → 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | o-CRESYL GLYCIDYL ETHER | HCID 16640 | — |
| 반응물 | 6-(2-Benzylamino-2,2-dimethylethoxy)-nicotinic acid amide | HCID 53961034 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol | HCID 21333233 | — |
반응 단계
A solution of 12 g of 6-(2-benzylamino-2,2-dimethylethoxy)-nicotinic acid amide and 12 g of 1-(2-methylphenoxy)2,3-epoxy-propane in 150 ml of isopropanol is boiled for 28 hours under reflux. After working up analogously to Example 1(c), crude 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol is obtained, which is used further without additional purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04027027 |
| 출처 데이터셋 | uspto-grants-1977_05 |
| ORD ID | ord-11cc49ab95dc4db1930c434929592b4a |
| 출처 메모 | uspto-grants-1977_05 |