Benzene, (2-chloroethoxy)- → Phenoxyethyl-norfentanyl

HRID 2399172

반응식

HRID 2399172 반응식
[C:1]1([N:7]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:8](=[O:11])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:18]([CH2:25][CH2:26]Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[O:18]([CH2:25][CH2:26][N:15]1[CH2:14][CH2:13][CH:12]([N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:11])[CH2:9][CH3:10])[CH2:17][CH2:16]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 12156Benzene, (2-chloroethoxy)-HCID 2593814-(N-Propionylaniline)piperidine

생성물 1

HCID 54005394Phenoxyethyl-norfentanyl수율 98.6%

실험 절차

By condensing 14.7 g 4-(N'-phenyl-N'-propionylamino)-piperidine and 19.9 g phenoxyethyl chloride, they are obtained after 24 hours reflux 22 g of the title product which after recrystallization from hot cyclohexane gives a first crop weighing 13.5 g. The pure compound melts at 100°-102°. It is soluble in hydrochloric acid. The solution after distillation leads to the recovery of the hydrochloride. The hydrochloride is soluble in water.

후처리

  1. customare obtained after 24 hours

출처 및 근거

ORD 기록
ord-06dc97e744cf48a0a7842a8396006747
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04027028

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