4-Bromoanisole → HCID 19387414, 화합물

HRID 2399272노트

반응식

HRID 2399272 반응식
[CH2:1]([C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([O:12]C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([Mg]Br)=[CH:22][CH:21]=1.[Mg].Br[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1>C1COCC1>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:10]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=2)([C:9]2[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=2[CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[OH:12])=[CH:22][CH:21]=1

참가 물질

6

반응물 4

HCID 77304-BromoanisoleHCID 2357302-Benzylbenzoic acid methyl esterHCID 5462224MagnesiumHCID 178491912HCID 178491912, 화합물

생성물 1

HCID 19387414HCID 19387414, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 2-benzylbenzoate (10.0 g) was added dropwise to a stirred solution of 4-methoxyphenyl magnesium bromide, which was prepared in situ from magnesium (3.2 g) and 4-bromoanisole (24.9 g), in THF at room temperature. After 16 hours, the mixture was quenched with ammonium chloride solution and the solvent evaporated in vacuoo The residue was extracted with ethyl acetate, dried (MgSO4), filtered, and evaporated in vacuo to give di-(4-methoxyphenyl)-(2-benzylphenyl)carbinol as an oil. This oil was dissolved in acetic acid (50 mL) and concentrated H2SO4 (2.0 mL) was added the resulting mixture was heated to 100° C. for one hour and then neutralized with NaOH solution. The mixture was extracted with ether and the organic extracts were combined, dried (MgSO4), filtered, evaporated in vacuo and chromatographed on silica gel eluting with hexane/ethyl acetate (10/1) to give 9,9-bis(4-methoxyphenyl)-(9H, 10H)-dihydroanthracene (7.1 g) as a solid. M.P. 138°-140° C. Demethylation was performed using the sodium ethanethiolate/DMF procedure described in Example 3 to give the title product in 77% yield as a solid. M.P. 230°-232° C.

후처리

  1. customthe mixture was quenched with ammonium chloride solution
  2. customthe solvent evaporated in vacuoo The residue
  3. extractionwas extracted with ethyl acetate
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-63cea2e6fbe74ff584c07e82fb4e826f
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05447960

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