Methyl Salicylate → HCID 9250987, 화합물

HRID 2399277노트

반응식

HRID 2399277 반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].Cl[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N+:19]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[O:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([O:10][CH3:11])=[O:9])([O-:21])=[O:20]

참가 물질

5

반응물 3

HCID 4133Methyl SalicylateHCID 69451-Chloro-2-nitrobenzeneHCID 11430Potassium Carbonate

생성물 1

HCID 9250987HCID 9250987, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl salicylate (1.7 mL, 0.0131 mol), 1-chloro-2-nitrobenzene (2.30 mL, 0.01965 mol) and potassium carbonate (3.62 g, 0.0262 mol) were mixed in dimethylformamide (35 mL), under argon, at 150° C. for 16 h. The solvent was evaporated and the crude material was flash chromatographed (silica gel, ethyl acetate/hexane). Concentration in vacuo yielded the title compound. 1H NMR (250 MHz, CDCl3) δ8.0 (m, 4H), 7.58 (m, 1H), 7.35 (m, 1H), 7.23 (m, 1H), 7.13 (dd, 1H), 6.85 (dd, 2H).

후처리

  1. customThe solvent was evaporated
  2. customchromatographed (silica gel, ethyl acetate/hexane)
  3. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-11314236eab64891bef81af358e843c9
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05447957

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