Sodium Cyanide → HCID 18973689, 화합물

HRID 2399414노트

반응식

HRID 2399414 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9]Cl)[CH2:3][CH2:2]1.[C-:18]#[N:19].[Na+]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH2:9][C:18]#[N:19])[CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 8929Sodium CyanideHCID 18973686HCID 18973686, 화합물

생성물 1

HCID 18973689HCID 18973689, 화합물수율 95.7%

실험 절차

To 3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride (26 g) in dimethylflormamide (150 mL) under an argon atmosphere was added sodium cyanide (9.7 g, 198 mmol). The resulting mixture was stirred at room temperature and heated gently for 2 h, then cooled and concentrated. The mixture was partitioned between basic brine and ether and extracted twice. The organic extract was washed with brine and was dried (sodium sulfate). The solvent was removed in vacuo to provide an orange-brown oil (24 g), which was used without purification.

후처리

  1. temperatureheated gently for 2 h
  2. temperaturecooled
  3. concentrationconcentrated
  4. customThe mixture was partitioned between basic brine and ether
  5. extractionextracted twice
  6. extractionThe organic extract
  7. washwas washed with brine
  8. dry with materialwas dried (sodium sulfate)
  9. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-a1dbcaa1f8484773b9b4c71d9207d02b
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05449686

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