Dodecanoyl chloride → HCID 9865002, 화합물

HRID 2399912노트

반응식

HRID 2399912 반응식
[OH:1][CH2:2][C:3]1[CH:7]([CH3:8])[O:6][C:5](=[O:9])[C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:16](Cl)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].C(N(CC)CC)C.CN(C1C=CC=CN=1)C>C1COCC1>[C:16]([O:1][CH2:2][C:3]1[CH:7]([CH3:8])[O:6][C:5](=[O:9])[C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

참가 물질

6

반응물 4

HCID 8166Dodecanoyl chlorideHCID 8471TriethylamineHCID 218852-DimethylaminopyridineHCID 15295494HCID 15295494, 화합물2회

생성물 1

HCID 9865002HCID 9865002, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Hydroxymethyl-5-methyl-3-phenyl-2(5H)-furanone (Compound 7), (73 mg, 0.36 mmol), lauroyl chloride (117 mg, 0.54 mmol), triethylamine (47 mg, 0.47 mmol) and dimethylaminopyridine (1 mg, 0.01 mmol) were stirred in anhydrous THF (2 mL) at ambient temperature under argon for 2 hours. The crude reaction mixture was concentrated, the organics were extracted into diethyl ether and solids were filtered off. The ether was removed by rotary evaporator and the resulting oil was purified by flash chromatography on silica to give the title compound.

후처리

  1. customThe crude reaction mixture
  2. concentrationwas concentrated
  3. extractionthe organics were extracted into diethyl ether and solids
  4. filtrationwere filtered off
  5. customThe ether was removed by rotary evaporator
  6. customthe resulting oil was purified by flash chromatography on silica

출처 및 근거

ORD 기록
ord-f6331677e6984201a1a4be3cf385bdea
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05451686

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