Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate → 3-Ethylaminomethyl-3-hydroxypyrrolidine
반응식
[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][N:7](C(OCC)=O)[CH2:6]1)[CH3:2]>O>[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:2]참가 물질
3
실험 절차
7.7 g (35.6 mmol) of ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate are heated under reflux overnight with 22 g of Ba(OH)2 . 8H2O in 220 ml of water. The mixture is filtered off with suction from BaCO3 and concentrated. The residue is boiled five times using 100 ml of dioxane each time, and the dioxane solution is concentrated and distilled.
후처리
- filtrationThe mixture is filtered off with suction from BaCO3
- concentrationconcentrated
- concentrationthe dioxane solution is concentrated
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-24145c24e110439ea0d37ab8abc38a9a
- 출처 데이터셋
- uspto-grants-1995_09
- 특허 번호
- US05453422
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