Methylamine → HCID 19382193, 화합물

반응식

[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]2)[CH2:2]1.[CH3:14][NH2:15]>>[OH:1][C:3]1([CH2:2][NH:15][CH3:14])[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1

참가 물질

반응물 2

HCID 6329Methylamine

HCID 13672926Ethyl 1-oxa-6-azaspiro[2,5]octane-6-carboxylate

생성물 1

HCID 19382193HCID 19382193, 화합물

실험 절차

5.2 g (28 mmol) of ethyl 6-aza-1-oxaspiro[2,5]-octane-6-carboxylate are added dropwise to 30 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and recrystallized from petroleum ether (hygroscopic crystals).

후처리

concentrationIt is then concentrated
customrecrystallized from petroleum ether (hygroscopic crystals)

출처 및 근거

ORD 기록: ord-fac9ac652b8749cf9bf84992d7ccf1be
출처 데이터셋: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05453422

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