1,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate → 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine

HRID 2400082노트

반응식

HRID 2400082 반응식
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[C:19]([O:18][C:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]

참가 물질

4

반응물 1

HCID 544893721,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate

생성물 1

HCID 537161023-(Boc-aMinoMethyl)-3-hydroxypyrrolidine

시약·촉매·용매 2

HCID 887Methanol용매HCID 23938Palladium용매

실험 절차

18.7 g (61 mmol) of 1-benzyl-3-tert.-butoxycarbonylaminomethyl-3-hydroxypyrrolidine are dissolved in 120 ml of methanol and hydrogenated on 3 g of 5% strength Pd/active carbon at 90° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is recrystallized from ethyl acetate.

후처리

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe residue is recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-792d1892bf3d4eee9a0d09dcacf84906
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453422

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