Water → HCID 178492676, 화합물

HRID 2400139노트

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HRID 2400139 반응식
[F:1][C:2]1[C:3]([NH2:9])=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16].O>N1C=CC=CC=1>[F:1][C:2]1[C:3]([NH:9][C:15](=[O:16])[C:14]2[CH:13]=[C:12]([O:11][CH3:10])[C:20]([O:21][CH3:22])=[C:19]([O:23][CH3:24])[CH:18]=2)=[N:4][C:5](=[O:8])[NH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 178509021HCID 178509021, 화합물

생성물 1

HCID 178492676HCID 178492676, 화합물수율 90.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

12.9 g of 5-fluorocytosine was suspended in 78 ml of pyridine, followed by addition of 23.1 g of 3,4,5-trimethoxybenzoyl chloride and stirring at 100° C. for 5 hours. The reaction mixture was cooled down to room temperature and then poured into 310 ml of water at room temperature over a period of 20 minutes. The precipitated crystals were collected by filtration to obtain 29.2 g (90.4%) of 5-fluro-N4 -(3,4,5-trimethoxybenzoyl)cytosine.

후처리

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. filtrationThe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-17bf57979d154eaf9743da8f3f9d9e25
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453497

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