Water → HCID 178492676, 화합물

HRID 2400140

반응식

HRID 2400140 반응식
[CH:1]1[C:7]([F:8])=[C:6]([NH2:9])[NH:5][C:3](=[O:4])[N:2]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16].O>N1C=CC=CC=1>[F:8][C:7]1[C:6]([NH:9][C:15](=[O:16])[C:14]2[CH:13]=[C:12]([O:11][CH3:10])[C:20]([O:21][CH3:22])=[C:19]([O:23][CH3:24])[CH:18]=2)=[N:5][C:3](=[O:4])[NH:2][CH:1]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 3366FlucytosineHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-

생성물 1

HCID 178492676HCID 178492676, 화합물수율 90.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a suspension of 12.9 g of fluorocytosine in 78 ml of pyridine was added 23.1 g of 3,4,5-trimethoxybenzoyl chloride, and the mixture was reacted at 100° C. for 5 hours. After the completion of reaction, the reaction mixture was poured into 300 ml of water at room temperature with stirring. After stirring the resulting mixture for additional 3 hours, the precipitated crystals were collected by filtration, washed with water and then dried to obtain 29.2 g of 5-fluoro-N4 -(3,4,5-trimethoxybenzoyl)cytosine.

후처리

  1. customthe mixture was reacted at 100° C. for 5 hours
  2. customAfter the completion of reaction
  3. stirringAfter stirring the resulting mixture for additional 3 hours
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-74bbda3b21bf49d39a67dd17c73c7013
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453497

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