Trifluoroacetic acid → 1-(2-Amino-4-chloro-5-methoxyphenyl)-3-methylpentan-2-ol

HRID 2400286노트

반응식

HRID 2400286 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([O:15][CH3:16])=[CH:10][C:9]=1[CH2:17][CH:18]([OH:23])[CH:19]([CH3:22])[CH2:20][CH3:21])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([O:15][CH3:16])=[CH:10][C:9]=1[CH2:17][CH:18]([OH:23])[CH:19]([CH3:22])[CH2:20][CH3:21]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 131731723HCID 131731723, 화합물

생성물 1

HCID 696710981-(2-Amino-4-chloro-5-methoxyphenyl)-3-methylpentan-2-ol수율 95.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl[5-chloro-2-(2-hydroxy-3-methylpentyl)-4-methoxyphenyl]carbamate (873 mg) in dichloromethane (12.2 mL) was added dropwise trifluoroacetic acid (3.76 mL) under ice-cooling, and this mixture was stirred for 9 hours. The reaction mixture was concentrated under reduced pressure. To the residue were added ethyl acetate and saturated aqueous sodium hydrogen carbonate solution to separate the organic layer. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (603 mg). 1H-NMR (CDCl3) δ ppm: 0.75-1.75 (9H, m), 2.45-2.85 (2H, m), 3.30-4.10 (6H, m), 6.60-6.80 (2H, m). ESI-MS (m/z): 258, 260 (M+H)+

후처리

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionTo the residue were added ethyl acetate and saturated aqueous sodium hydrogen carbonate solution
  4. customto separate the organic layer
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane)

출처 및 근거

ORD 기록
ord-355b552f146d4cc6a81560c75557cbfa
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796247B2

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