Ammonia → 2-Chloro-5-methoxypyrimidin-4-amine

HRID 2400339노트

반응식

HRID 2400339 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH3:10])=[CH:4][N:3]=1.[NH3:11]>CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:11])[C:5]([O:9][CH3:10])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 6014012,4-Dichloro-5-methoxypyrimidine

생성물 1

HCID 569495382-Chloro-5-methoxypyrimidin-4-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45 g, 2.5 mmol) and ammonia in methanol (2N, 20 ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+=160

후처리

  1. concentrationThe mixture was then concentrated in vacuo
  2. washwashed with water
  3. customThe residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether)

출처 및 근거

ORD 기록
ord-e3a34c5197bd42178377e0d632b1b333
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796244B2

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