Ammonia → 2,5-Dichloropyrimidin-4-amine
반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[CH:4][N:3]=1.[NH3:10]>CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:10])[C:5]([Cl:9])=[CH:4][N:3]=1참가 물질
4
실험 절차
A solution of 2,4,5-trichloropyrimidine (2.2 ml) in 2M ammonia in methanol (50 ml) was stirred at room temperature overnight. The reaction was then concentrated in vacuo and the resultant solid was washed with water. The residue was triturated with methanol and the solid was isolated by vacuum filtration to furnish the title compound as a white solid (487 mg). 1H NMR (400 MHz, DMSO-d6): 8.18 (1H, s).
후처리
- concentrationThe reaction was then concentrated in vacuo
- washthe resultant solid was washed with water
- customThe residue was triturated with methanol
- customthe solid was isolated by vacuum filtration
출처 및 근거
- ORD 기록
- ord-2b20d8dd70124d54a83649e35e8bd5b6
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08796244B2
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