Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Benzyloxyindole → 3-(5-Benzyloxy-indol-1-yl)-3-phenyl-acrylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Benzyloxyindole | HCID 14624 | — |
| 반응물 | Benzeneacetic acid, alpha-methyl-, ethyl ester | HCID 99643 | — |
| 반응물 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 3-(5-Benzyloxy-indol-1-yl)-3-phenyl-acrylic acid ethyl ester | HCID 67427786 | 68% |
반응 단계
A mixture of 5-benzyloxy-1H-indole (4.46 g, 20.0 mmol), phenyl-propionic acid ethyl ester (7.00 g, 40.0 mmol), and tetrabutylammonium fluoride [1.0 M in THF] (36.0 mL, 50.0 mmol) was stirred for 3 days. After removal of solvent, the crude reaction mixture was submitted to flash chromatography on silica gel with ethyl acetate/hexane (1:4) to give the title compound (5.42 g, 68% yield) as an E/Z isomeric mixture. Mass Spectrum (LCMS, ESI) calculated for C26H24NO3 398.2 (M+H); found 398.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855722B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-4efd4aef04b54ee0bfbdd869d97960bb |
| 출처 메모 | uspto-grants-2005_02 |