Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (3-pyridin-3-yl-phenyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid | HCID 234562 | — |
| 반응물 | 3-(Pyridin-3-yl)aniline | HCID 459521 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (3-pyridin-3-yl-phenyl)-amide | HCID 86650367 | 84% |
반응 단계
DIEA (43.5 μL, 0.25 mmol) was added to 8-methoxy-3-carboxy-coumarin (50.0 mg, 0.23 mmol) and HATU (95.0 mg, 0.25 mmol) in 1 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-pyridin-3-yl-phenylamine (38.7 mg, 0.23 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 71.6 mg of product in 84% yield: LCMS (ESI) m/z 373 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642788B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-cd768fd000b74994a6aef355194d60bc |
| 출처 메모 | uspto-grants-2014_02 |