홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Oxalyl chloride → 5-Methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbonyl chloride

HRID 2400567
노트
인쇄 미리보기

반응식

HRID 2400567 반응식
[CH3:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:15]([OH:17])=O)[CH:3]=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C=O)C>[CH3:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:15]([Cl:21])=[O:17])[CH:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 27470481-(4-Methylbenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid2회

생성물 1

HCID 595047005-Methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbonyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

반응 조건

온도
0 °C
이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

실험 절차

5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid (Intermediate B, 390 mg, 1.69 mmol), was dissolved in dichloromethane (26 mL) and cooled to 0° C. Oxalyl chloride was added (0.79 mL, 8.47 mmol) along with 1 drop of DMF. The ice bath was removed and the mixture was stirred at rt for 30 min before the solvent was evaporated. The residue was used in the next step with no further purification or characterization.

후처리

  1. customThe ice bath was removed
  2. customwas evaporated
  3. customThe residue was used in the next step with no further purification or characterization

출처 및 근거

ORD 기록
ord-61571747528f462a837d99fc162db6d3
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08796253B2

반응 노트

불러오는 중…