Potassium tert-butoxide → 2-(5-Bromo-pyrazin-2-yl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

To a solution of 4-[2-(5-bromo-pyrazin-2-ylamino)-ethyl]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (0.825 g, 1.81 mmols) in THF (10 mL) was added a 1 M solution of potassium t-butoxide in THF (2.0 mL), and allowed to stir at room temperature. After 1 hour LCMS was taken and reaction was not complete. After 5 hours, an additional 1 mL of potassium t-butoxide was added. The reaction mixture was allowed to stir for 16 hours. The three reaction mixtures were diluted with ethyl acetate (20 mL), quenched with water (5 mL). The aqueous layer was extracted with EtOAc (2×10 mL). The combined organic layers were washed with brine, dried over Na2SO4, and concentrated under vacuum to afford crude product. Purification over silica gel eluting with methanol in dichloromethane (0-10%) afforded 0.186 g (25%) of the title compound.

1. customreaction
2. waitAfter 5 hours
3. stirringto stir for 16 hours
4. customThe three reaction mixtures
5. customquenched with water (5 mL)
6. extractionThe aqueous layer was extracted with EtOAc (2×10 mL)
7. washThe combined organic layers were washed with brine
8. dry with materialdried over Na2SO4
9. concentrationconcentrated under vacuum
10. customto afford crude product
11. customPurification over silica gel eluting with methanol in dichloromethane (0-10%)

ORD 기록

ord-eff813216728484da0543360c681b540

출처 데이터셋

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08796278B2