Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | HCID 15563630 | HCID 15563630 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine | HCID 86677016 | 81% |
반응 단계
11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08796284B2 |
| 출처 데이터셋 | uspto-grants-2014_08 |
| ORD ID | ord-ab2294b0b0e240c9a93440f63ec30081 |
| 출처 메모 | uspto-grants-2014_08 |