Water → 5-bromo-6-(phenylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

HRID 2401166

반응식

HRID 2401166 반응식
[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1Cl.[C:15]1([SH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])([O-])=O.[Cs+].[Cs+].O>C1COCC1>[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1[S:21][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7969ThiophenolHCID 10796Cesium carbonateHCID 866770175-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine2회

생성물 1

HCID 574072415-bromo-6-(phenylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 0.1 g (0.36 mmol) of 5-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine (Intermediate 5) in 4 ml of THF, 74 μl (0.73 mmol) of thiophenol and 0.178 g (0.55 mmol) of Cs2CO3 were added. The mixture was allowed to react under microwave conditions 15 min. at 100° C. Afterwards the reaction mixture was put on 10 ml of cool water. The formed white precipitate was filtered, washed several times with cold water and dried.

후처리

  1. customto react under microwave conditions 15 min. at 100° C
  2. filtrationThe formed white precipitate was filtered
  3. washwashed several times with cold water
  4. customdried

출처 및 근거

ORD 기록
ord-3e7636f6b0f44df19073227f73ac74c2
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796284B2

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