Sodium Azide → 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine-4,6-diamine

HRID 2401168

반응식

HRID 2401168 반응식
[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1Cl.[N-:15]=[N+]=[N-].[Na+]>O1CCOCC1>[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1[NH2:15]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 866770175-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine2회

생성물 1

HCID 534678255-bromo-2-(1H-pyrazol-1-yl)pyrimidine-4,6-diamine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 0.10 g (0.37 mmol) of 5-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidine-4-amine (Intermediate 5) and 0.05 g (0.77 mmol) of sodium azide in dioxane (10 mL) was stirred at 80° C. for 6 h. The solvent was then evaporated, and the residue dissolved in methanol, Pd on charcoal added (10 mg) and hydrogenated for 30 min. The solvent was again evaporated and the residue crystallizes from ethanol.

후처리

  1. customThe solvent was then evaporated
  2. dissolutionthe residue dissolved in methanol
  3. additionPd on charcoal added (10 mg)
  4. customThe solvent was again evaporated
  5. customthe residue crystallizes from ethanol

출처 및 근거

ORD 기록
ord-3c2b21ac9b854f46891fa63dd5814f14
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796284B2

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