Ammonia → HCID 178513697, 화합물

HRID 2401177노트

반응식

[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10]CC)=O)[CH:3]=1.[NH3:13]>>[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH2:13])=[O:10])[CH:3]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 178469368HCID 178469368, 화합물2회

생성물 1

HCID 178513697HCID 178513697, 화합물수율 68.4%

실험 절차

Ethyl 6-hydroxy-4-pyrimidinecarboxylate (Intermediate 6, 0.995 g, 5.92 mmol) was treated with 0.88 ammonia solution (9.95 mL, 460 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 18 hours. The resulting solid was collected by filtration, taken up in toluene and the solvent removed under reduced pressure to give the title compound as a yellow solid (563 mg);

후처리

filtrationThe resulting solid was collected by filtration
customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록: ord-8707f8fbf2ae48cd97769a773ef24e81
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08796283B2

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