Water → AC1Lgxvo

HRID 2401263노트

반응식

HRID 2401263 반응식
Cl.[NH2:2][C@H:3]([C:7]([NH2:9])=[O:8])[CH:4]([CH3:6])[CH3:5].[C:10](=O)([O-])[OH:11].[Na+].ClC(OC1C=CC([N+]([O-])=O)=CC=1)=O.O>C(#N)C>[CH3:5][CH:4]([C@@H:3]1[NH:2][C:10](=[O:11])[NH:9][C:7]1=[O:8])[CH3:6]

참가 물질

6

반응물 4

HCID 962WaterHCID 821294-Nitrophenyl chloroformateHCID 516892Sodium BicarbonateHCID 13689583L-Valinamide--hydrogen chloride (1/1)

생성물 1

HCID 853633AC1Lgxvo수율 58%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a suspension of L-valinamide hydrochloride (1.0 g) and sodium hydrogen carbonate (3.03 g) in acetonitrile (100 mL) was added p-nitrophenyl chloroformate (1.32 g), and the mixture was stirred at room temperature for 3 hr. Water was added thereto, the resulting mixture was stirred at room temperature overnight, and then acetonitrile was distilled off under reduced pressure. After extraction with ethyl acetate, the organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel cartridge, chloroform/methanol) to afford (5S)-5-(propan-2-yl)imidazolidine-2,4-dione (540 mg).

후처리

  1. stirringthe resulting mixture was stirred at room temperature overnight
  2. distillationacetonitrile was distilled off under reduced pressure
  3. extractionAfter extraction with ethyl acetate
  4. concentrationthe organic layer was concentrated under reduced pressure
  5. customThe residue was purified by column chromatography (silica gel cartridge, chloroform/methanol)

출처 및 근거

ORD 기록
ord-132f745f687b4f7aba5188080f1dee15
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796272B2

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