1-(Bromomethyl)-3-chlorobenzene → 4-(3-Chlorobenzyl)-4-(2-methylpropane-2-sulphinylamino)-piperidine-1-carboxylic acid tert-butyl ester

A solution of N-BOC-piperidone (0.205 g, 1.03 mmol), t-butylsulphinamide (0.13 g, 1.07 mmol) and titanium tetraethoxide (0.42 ml, 2.0 mmol) in dry THF (5 ml) was refluxed under nitrogen for 5 h. The cooled solution was diluted with brine (10 ml) and ethyl acetate (10 ml). The suspension was shaken, the filtered through Celite, washing with ethyl acetate (10 ml). The two-phase filtrate was separated and the organic layer was dried (Na2SO4) filtered and concentrated to give the crude sulphinimine (0.293 g). The crude sulphinimine (0.293 g) was suspended in dry THF (2 ml) and stirred at room temperature under nitrogen. A solution of 3-chlorobenzyl magnesium bromide (ca. 4 mmol) (freshly prepared as a solution in diethyl ether from 3-chlorobenzylbromide and magnesium turnings) was added to give an orange solution. After 3 hours, the mixture was diluted with saturated aqueous ammonium chloride (20 ml) and extracted with ethyl acetate (20 ml). The extract was washed with water (20 ml), brine (10 ml), dried (Na2SO4), filtered and concentrated. Flash column chromatography, eluting with 50% ethyl acetate—hexanes, gave 4-(3-chlorobenzyl)-4-(2-methylpropane-2-sulphinylamino)-piperidine-1-carboxylic acid tert-butyl ester as a straw-coloured foam (0.139 g, 0.324 mmol, 31%). LC-MS (LCT) m/z 451, 453 [M+Na+], Rt 8.22 min.

1. filtrationthe filtered through Celite
2. washwashing with ethyl acetate (10 ml)
3. customThe two-phase filtrate was separated
4. dry with materialthe organic layer was dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customto give the crude sulphinimine (0.293 g)
8. stirringstirred at room temperature under nitrogen
9. additionwas added
10. customto give an orange solution
11. extractionextracted with ethyl acetate (20 ml)
12. washThe extract was washed with water (20 ml), brine (10 ml)
13. dry with materialdried (Na2SO4)
14. filtrationfiltered
15. concentrationconcentrated
16. washFlash column chromatography, eluting with 50% ethyl acetate—hexanes

ORD 기록

ord-9f92ae3c1692421b962c9400218bed71

출처 데이터셋

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08796293B2