4-Fluorobenzylamine → HCID 67482556, 화합물
반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:12])[NH:5][C:6]2=[O:11].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]N)=[CH:16][CH:15]=1>C(O)(=O)C>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:12])[N:5]([CH2:18][C:17]1[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=1)[C:6]2=[O:11]참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
A mixture of 4-chloro-isoindole-1,3-dione (2.75 g, 15 mmol) and 4-fluorobenzylamine (1.88 g, 15 mmol) in glacial acetic acid (10 mL) was heated at 150° C. in microwave for 30 mins. After cooled to room temperature, the reaction mixture was poured into ice water and the white precipitates were collected. Recrystallization with EtOH provided the title compound (3.86 g, 89%).
후처리
- temperatureAfter cooled to room temperature
- customthe white precipitates
- customwere collected
- customRecrystallization with EtOH
출처 및 근거
- ORD 기록
- ord-f8c12a5b93474e49a8919040bfbe3b97
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08796313B2
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