Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-Bromo-5-fluorobenzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzoic acid, 2-bromo-5-fluoro-, methyl ester | HCID 138875 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Bromo-5-fluorobenzyl alcohol | HCID 2773349 | — |
반응 단계
To a solution of methyl 2-bromo-5-fluorobenzoate (10, 21.30 g, 91.4 mmol) in dry THF (150 mL) was added NaBH4 (6.95 g, 183 mmol). Methanol (20 mL) was added dropwise at RT. After the addition, the mixture was stirred at RT for 1 h. Water (200 mL) was slowly added. The mixture was extracted with CH2Cl2 (100 mL×2). The combined extracts were washed with saturated NaHCO3 and brine, dried over MgSO4 and concentrated to give (2-bromo-5-fluorophenyl)methanol (11).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648073B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-f680df50dc154f649f0aca6fe6f78b8d |
| 출처 메모 | uspto-grants-2014_02 |