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Potassium Carbonate → HCID 67308753, 화합물

HRID 240304
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인쇄 미리보기

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HRID 240304 반응식
[C:1]([O:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([OH:13])[CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17](=[O:34])[CH:18](Br)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32].C([O-])([O-])=O.[K+].[K+]>CC#N>[C:1]([O:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][C:17]([O:16][CH3:15])=[O:34])[CH:8]=1)([CH3:4])([CH3:2])[CH3:3]
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 13382081tert-Butyl 3-hydroxybenzoateHCID 13706912Methyl 2-bromohexadecanoate

생성물 1

HCID 67308753HCID 67308753, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
80 °C

실험 절차

3-Hydroxy-benzoic acid tert-butyl ester (1.79 g) was dissolved in MeCN 75 ml, then bromo-hexadecanoic acid methyl ester (3.22 g) was added followed by K2CO3 (2.5 g). The reaction was stirred for 3 d at 80° C. The reaction mixture was filtered. The filtrate was evaporated, and the residue was dissolved in EtOAc 100 ml, and the EtOAc layer was washed twice with 100 ml brine. The organic layer was dried over MgSO4 filtered and the solvent was removed by evaporation to give 4.165 g (98%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customThe filtrate was evaporated
  3. dissolutionthe residue was dissolved in EtOAc 100 ml
  4. washthe EtOAc layer was washed twice with 100 ml brine
  5. dry with materialThe organic layer was dried over MgSO4
  6. filtrationfiltered
  7. customthe solvent was removed by evaporation
  8. customto give 4.165 g (98%)

출처 및 근거

ORD 기록
ord-f654cb97308f4fcd975925401b1ca48c
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08648041B2

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