Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 178471968, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile | HCID 292929 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178471968 | HCID 178471968 | 97.3% |
반응 단계
Ethylcyanoacetate (110 mg, 0.970 mmol) was dissolved, under inert atmosphere, in dry DMF (1 ml) and NaH (39 mg, 0.970 mmol) was added in one portion. After 30 min, a solution of 1 (150 mg, 0.646 mmol) in dry DMF (2 ml) was added dropwise. After 15 min MeOH was added and the solution stirred for 10 min. The solvents were evaporated and the crude purified by flash chromatography (EtOAc:MeOH 9:1) affording 22 as a dark red solid (200 mg, 97%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648076B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-acdda630ff26422c8d67586bdcbc4117 |
| 출처 메모 | uspto-grants-2014_02 |