(2S,4R)-tert-butyl 4-(2-chlorophenylsulfonyl)-2-(1-cyanocyclopropylcarbamoyl)-pyrrolidine-1-carboxylate → (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

HRID 2403148노트

반응식

HRID 2403148 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][N:14](C(OC(C)(C)C)=O)[C@H:13]([C:23](=[O:30])[NH:24][C:25]2([C:28]#[N:29])[CH2:27][CH2:26]2)[CH2:12]1)(=[O:10])=[O:9]>C(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][NH:14][C@H:13]([C:23]([NH:24][C:25]2([C:28]#[N:29])[CH2:27][CH2:26]2)=[O:30])[CH2:12]1)(=[O:10])=[O:9]

참가 물질

3

반응물 1

HCID 66771127(2S,4R)-tert-butyl 4-(2-chlorophenylsulfonyl)-2-(1-cyanocyclopropylcarbamoyl)-pyrrolidine-1-carboxylate

생성물 1

HCID 46946413(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide수율 85%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

The reaction of the amide 6H with formic acid yielded (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide as a white foam (85%). MS ISP (m/e): 354.2 (100) [(M+H)]+.

출처 및 근거

ORD 기록
ord-4c36f38f972c4920ac083827fc190e62
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08802665B2

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