1,3-Diethyl 2-oxopropanedioate → HCID 68476438, 화합물

HRID 240339노트

반응식

HRID 240339 반응식
[NH2:1][C:2]1[C:3]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.O=[C:16]([C:22](OCC)=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(O)C>[O:23]=[C:22]1[N:8]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:16]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]

참가 물질

4

반응물 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 106790912-N-phenylpyridine-2,3-diamine

생성물 1

HCID 68476438HCID 68476438, 화합물수율 58%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

11.68 g (63 mmol) of 3-amino-2-anilinopyridine was dissolved in ethanol (150 mL), and 12.07 g (69 mmol) of diethyl ketomalonate was added thereto. The mixture was heated to reflux for 4 hours while stirring. After confirming the completion of the reaction, the reaction solution was cooled to room temperature, and the solvent was distilled off under reduced pressure. The residue thus obtained was washed using diisopropyl ether, to obtain 10.74 g (yield: 58%) of ethyl 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate as pale yellow crystals.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customthe completion of the reaction
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue thus obtained
  6. washwas washed

출처 및 근거

ORD 기록
ord-c3f84edb831348a89ae03de8728ec866
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648075B2

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