Isopropyl iodide → 2-{[(1S)-1-Methylbutyl]oxy}-9-{2-[1-(1-methylethyl)-3-piperidinyl]ethyl}-8-(methyloxy)-9H-purin-6-amine
반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([CH2:9][CH2:10][N:11]2[C:19]([O:20][CH3:21])=[N:18][C:17]3[C:12]2=[N:13][C:14]([O:23][C@@H:24]([CH3:28])[CH2:25][CH2:26][CH3:27])=[N:15][C:16]=3[NH2:22])[CH2:4]1)[CH3:2].[CH3:29][C@H](OC1N=C2C(N=C(OC)N2CCC2CCCNC2)=C(N)N=1)CCC.IC(C)C>>[CH3:28][C@H:24]([O:23][C:14]1[N:13]=[C:12]2[C:17]([N:18]=[C:19]([O:20][CH3:21])[N:11]2[CH2:10][CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][N:3]([CH:1]([CH3:29])[CH3:2])[CH2:4]2)=[C:16]([NH2:22])[N:15]=1)[CH2:25][CH2:26][CH3:27]참가 물질
4
반응물 3
생성물 1
실험 절차
Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine and 2-iodopropane.