Isobutyl iodide → 6-Amino-2-(butyloxy)-9-{[1-(2-methylpropyl)-4-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

반응식

[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:22]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[C:8]([NH2:24])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH2:26][CH:27]([CH3:29])[CH3:28]>>[NH2:24][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:22])[N:12]2[CH2:15][CH:16]1[CH2:17][CH2:18][N:19]([CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:20][CH2:21]1

참가 물질

반응물 2

HCID 10556Isobutyl iodide

HCID 583062032-(Butyloxy)-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine

생성물 1

HCID 672332916-Amino-2-(butyloxy)-9-{[1-(2-methylpropyl)-4-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

실험 절차

Prepared similarly to Example 24 from 2-(butyloxy)-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine and 1-iodo-2-methylpropane.

출처 및 근거

ORD 기록: ord-1765e7dbf1f04342b43ca8065e964251
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08802684B2

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