Ethanol hydrochloride → 4-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride

HRID 240403노트

반응식

HRID 240403 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[F:23])[CH2:5][C:6]1([OH:19])[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:24].C(O)C>C(O)C>[ClH:24].[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[F:23])[CH2:5][C:6]1([OH:19])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 21887872Ethanol hydrochlorideHCID 86680862Tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate

생성물 1

HCID 866808634-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate (4.7 g) in ethanol (30 mL) was added 2.0 M HCl/ethanol solution (36 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethyl acetate/diisopropyl ether to give the title compound (3.5 g).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained solid was recrystallized from ethyl acetate/diisopropyl ether

출처 및 근거

ORD 기록
ord-645c91a4b6f64796aa508ed09185e7cb
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648079B2

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