5-Methoxycarbonyl-2-methylphenylboronic acid → 3-[5-(2,6-Difluoro-benzoylamino)-thiophen-2-yl]4-methyl-benzoic acid methyl ester
반응식
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9](C2C=CC=C(C(F)(F)F)C=2)=[CH:10][CH:11]=1)=[O:5].[CH3:27][O:28][C:29]([C:31]1[CH:32]=[CH:33][C:34]([CH3:40])=[C:35](B(O)O)[CH:36]=1)=[O:30]>>[CH3:27][O:28][C:29](=[O:30])[C:31]1[CH:32]=[CH:33][C:34]([CH3:40])=[C:35]([C:9]2[S:8][C:7]([NH:6][C:4](=[O:5])[C:3]3[C:2]([F:1])=[CH:25][CH:24]=[CH:23][C:22]=3[F:26])=[CH:11][CH:10]=2)[CH:36]=1참가 물질
3
실험 절차
Compound 118 was synthesized in an analogous fashion as described for Compound 117 except that 5-methoxycarbonyl-2-methylbenzeneboronic acid was used instead of 3-trifluoromethylbenzeneboronic acid in the final step.
출처 및 근거
- ORD 기록
- ord-b14776d471d640aebfe57fe6578f2b55
- 출처 데이터셋
- uspto-grants-2014_08