Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitro-1H-indole → 4-Aminoindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitro-1H-indole | HCID 145766 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Aminoindole | HCID 583431 | — |
반응 단계
A round-bottom flask was charged with 4-nitroindole (4.8 g, 30 mmol), Palladium on carbon (10%, 480 mg), and THF (50 mL), and the mixture was stirred under one hydrogen atmosphere overnight. TLC showed the reaction was complete. The catalyst was filtered off and the filtrate was concentrated to afford 4-amino-1H-indole, which was used directly in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648086B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-c9141032da62429ea72e176f8ff59e25 |
| 출처 메모 | uspto-grants-2014_02 |