4-Chloro-2-isocyanato-1-methoxybenzene → 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea

HRID 240469노트

반응식

HRID 240469 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([N:8]=[C:9]=[O:10])[CH:7]=1.[NH2:13][C:14]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:15]=1[CH:16]=[CH:17][NH:18]2>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([NH:8][C:9]([NH:13][C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)=[O:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 1440094-Chloro-2-isocyanato-1-methoxybenzeneHCID 5834314-Aminoindole

생성물 1

HCID 666135101-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea수율 70%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 5-chloro-2-methoxyphenyl isocyanate (Int-4, 5.5 g, 30 mmol) in DCM (20 mL) was added dropwise to the 4-amino-1H-indole in DCM (30 mL) from Step A, and the resulting mixture was stirred overnight, then filtered to give the crude product 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea (6.6 g, 70%), which was used directly in the next step without purification.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-de54c33bb23a4aabacae83b75d98320b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648086B2

반응 노트

불러오는 중…