3-(Propan-2-yloxy)aniline → 6-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

HRID 240492

반응식

HRID 240492 반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8](Cl)=[O:9])[CH:5]=[N:4][CH:3]=1.[CH:11]([O:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18])([CH3:13])[CH3:12]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:18][C:17]2[CH:19]=[CH:20][CH:21]=[C:15]([O:14][CH:11]([CH3:13])[CH3:12])[CH:16]=2)=[O:9])[CH:5]=[N:4][CH:3]=1

참가 물질

4

반응물 2

HCID 5732203-(Propan-2-yloxy)anilineHCID 151496716-Chloropyrazine-2-carbonyl chloride

생성물 1

HCID 848200206-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from Example 15B was reacted with 3-isopropoxyaniline and TEA in CH2Cl2 as described in Example 15C to afford the title compound. MS (DCI/NH3) m/z 309 (M+H)+.

출처 및 근거

ORD 기록
ord-034f9027d7134397ba6c3fe5d835148b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648084B2

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