Trifluoroacetic acid → 4-(2-Methyl-4-nitrophenoxy)pyridin-2-amine
반응식
[CH3:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH:11]C(=O)OC(C)(C)C)[CH:6]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH2:11])[CH:6]=1참가 물질
4
실험 절차
To a solution of tert-butyl 4-(2-methyl-4-nitrophenoxy)pyridin-2-ylcarbamate (1.0 g, 2.90 mmol) in dichloromethane (28 mL) was added TFA (4 mL). After stirring at room temperature for 6 hours, the reaction mixture was concentrated under reduced pressure to provide the crude product that was used without further purification.
후처리
- concentrationthe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-976a2f84746c485d8bbd97c52a310b21
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08648087B2
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