N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamine → 4-(4-amino-2-methylphenoxy)-N1-methylbenzene-1,2-diamine

HRID 240558노트

반응식

HRID 240558 반응식
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2[CH3:19])=[CH:5][C:4]=1[N+:20]([O-])=O.[H][H]>C(OCC)(=O)C.C(O)C.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:6]2[CH:5]=[C:4]([NH2:20])[C:3]([NH:2][CH3:1])=[CH:8][CH:7]=2)=[C:11]([CH3:19])[CH:12]=1

참가 물질

6

반응물 2

HCID 86650896N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 669371924-(4-amino-2-methylphenoxy)-N1-methylbenzene-1,2-diamine

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamine (1.90 g, 6.27 mmol) in ethyl acetate (10 mL) and ethanol (20 mL) was added 10% Pd/C (0.342 g, 0.321 mmol). After shaking under 50 psi of hydrogen for 1 hour, the mixture was filtered and the filtrate was concentrated under reduced pressure to provide the product as clear oil.

후처리

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9235edec2efb4c5786933c8050ce5fc7
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648087B2

반응 노트

불러오는 중…