참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | HCID 178526470 | HCID 178526470 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 4-Chloro-6-nitroquinazoline | HCID 11356257 | — |
반응 단계
To a solution of 6-nitroquinazolin-4-ol (4.40 g, 23.01 mmol) and N-ethyl-N-isopropylpropan-2-amine (11.89 g, 92.04 mmol) in dichloroethane (50 mL) was added phosphoryl trichloride (7.06 g, 46.02 mmol). After heating to 80° C. for 16 hours, the mixture was concentrated under reduced pressure. The residue was concentrated again with toluene (2×100 mL) to provide the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08648087B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-d1eed894f6634d29a3b589e41d38d8f6 |
|---|
| 출처 메모 | uspto-grants-2014_02 |
|---|
