(S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate → (S)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate

HRID 240594노트

반응식

HRID 240594 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:22]([O-])=O)=[C:6]([CH:21]=1)[O:7][C@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9]1>CO.[Pd]>[NH2:22][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:21][C:6]=1[O:7][C@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]([O:16][C:17]([CH3:19])([CH3:20])[CH3:18])=[O:15])[CH2:9]1

참가 물질

4

반응물 1

HCID 58413048(S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate

생성물 1

HCID 58413089(S)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate (6.41 g) in MeOH (70.0 ml) was added palladium on charcoal (600.0 mg), the mixture hydrogenated at room temperature and 50 psi. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica chromatography to give the desired product.

후처리

  1. customhydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica chromatography

출처 및 근거

ORD 기록
ord-88c079872f0242228e04ee046c9b1af7
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648068B2

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