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Ammonia → 4-[4-Chloro-2-((S)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide

HRID 240623
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HRID 240623 반응식
CO[C:3]([C:5]1[S:34][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=3[O:21][C@H:22]3[CH2:27][CH2:26][CH2:25][N:24](C(=O)C(F)(F)F)[CH2:23]3)[C:7]=2[C:6]=1[CH3:35])=[O:4].[NH3:36]>CO>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:35])=[C:5]([C:3]([NH2:36])=[O:4])[S:34][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([O:21][C@H:22]2[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:16]=1
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참가 물질

4

반응물 2

HCID 222AmmoniaHCID 584132164-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

생성물 1

HCID 584131444-[4-Chloro-2-((S)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide

시약·촉매·용매 1

HCID 887Methanol용매

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온도
100 °C

실험 절차

4-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (150 mg) and ammonia in methanol (7M; 5 ml) were combined and heated at 100° C. in sealed tube. The reaction heated under these conditions for 48 h. The residue was purified by chromatography tho give the inteded product.

후처리

  1. temperatureThe reaction heated under these conditions for 48 h
  2. customThe residue was purified by chromatography
  3. customtho give the inteded product

출처 및 근거

ORD 기록
ord-345aec5582ec4f23bfbb98a83d6ad2ef
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08648068B2

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