(S)-1-Phenylbutylamine → (S)-2-cyano-N-(1-phenylbutyl)acetamide

반응식

[C:1]([CH2:3][C:4]([NH:6][CH:7]([C:11]1[CH:16]=[CH:15][C:14](OCCN(CC)CC)=[CH:13][CH:12]=1)[CH2:8][CH2:9][CH3:10])=[O:5])#[N:2].C1([C@@H](N)CCC)C=CC=CC=1>>[C:1]([CH2:3][C:4]([NH:6][C@H:7]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:9][CH3:10])=[O:5])#[N:2]

참가 물질

반응물 2

HCID 2449444(S)-1-Phenylbutylamine

HCID 668220192-Cyano-N-(1-(4-(2-(diethylamino)ethoxy)phenyl)butyl)acetamide

생성물 1

HCID 66822152(S)-2-cyano-N-(1-phenylbutyl)acetamide수율 58%

실험 절차

The title compound was prepared by using a similar procedure as described for the preparation of 29 except that (S)-1-phenylbutylamine was used instead of 1-(4-(2-(diethylamino)ethoxy)phenyl)butan-1-amine (25). This produced crude product which was purified by flash silica gel column chromatography, eluting with 7:3 hexanes/ethyl acetate, to give 39 (375 mg, 58%) as a white solid: MS (ES+) m/z 217.1.1 (M+H)+.

후처리

customThe title compound was prepared
customThis produced crude product which
customwas purified by flash silica gel column chromatography
washeluting with 7:3 hexanes/ethyl acetate

출처 및 근거

ORD 기록: ord-2bbccb3301ad4c8a967df9b2b3cdb307
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08809377B2

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