(E)-(2-(2-(2-(4-(1-(3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid, 1,3-bis-tert-butyl ester → N-(2-(2-(2-(4-(1-((E)-3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
반응식
[Br:1][C:2]1[N:7]=[C:6](/[CH:8]=[C:9](\C#N)/[C:10]([NH:12][CH:13]([C:17]2[CH:47]=[CH:46][C:20]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][NH:30][C:31](=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][C@H:36]3[C@@H:43]4[C@@H:39]([NH:40][C:41](=[O:44])[NH:42]4)[CH2:38][S:37]3)=[CH:19][CH:18]=2)[CH2:14][CH2:15][CH3:16])=[O:11])[CH:5]=[CH:4][CH:3]=1.BrC1N=C(/C=C/C(NC(C2C=CC(OCCOCCOCCN(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=CC=2)CCC)=O)C=CC=1>>[Br:1][C:2]1[N:7]=[C:6](/[CH:8]=[CH:9]/[C:10]([NH:12][CH:13]([C:17]2[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][NH:30][C:31](=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][C@H:36]3[C@@H:43]4[C@@H:39]([NH:40][C:41](=[O:44])[NH:42]4)[CH2:38][S:37]3)=[CH:46][CH:47]=2)[CH2:14][CH2:15][CH3:16])=[O:11])[CH:5]=[CH:4][CH:3]=1참가 물질
3
반응물 2
HCID 86762605(E)-(2-(2-(2-(4-(1-(3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid, 1,3-bis-tert-butyl ester
HCID 87168264N-(2-(2-(2-(4-(1-((E)-3-(6-Bromopyridin-2-yl)-2-cyanoacrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide생성물 1
실험 절차
The title compound was prepared by using a similar procedure as described for the preparation of 48 except that acrylamide 50 was used instead of cyanoacrylamide 47. This produced the crude product which was purified by flash silica gel column chromatography, eluting with 7:93 methanol/dichloromethane, to give 51 (50 mg, quantitative) as a clear oil: MS (ES+) m/z 731.2 (M+H)+.
후처리
- customThis produced the crude product which
출처 및 근거
- ORD 기록
- ord-9f2778eee3994103bb0b59c26655ed81
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08809377B2
반응 노트
불러오는 중…