C(OC([N:8]1[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[S:40][C:21]3[N:22]=[CH:23][N:24]=[C:25]([NH:26][C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=4[O:34][C@H:35]4[CH2:39][CH2:38][O:37][CH2:36]4)[C:20]=3[C:19]=2[CH3:41])=[O:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[NH:8]1[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[S:40][C:21]3[N:22]=[CH:23][N:24]=[C:25]([NH:26][C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=4[O:34][C@H:35]4[CH2:39][CH2:38][O:37][CH2:36]4)[C:20]=3[C:19]=2[CH3:41])=[O:17])[CH2:10][CH2:9]1A mixture of 380 mg (0.65 mmol) 4-[(4-{4-fluoro-2-[(S)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carbonyl)-amino]-azepane-1-carboxylic acid tert-butyl ester and 0.15 ml trifluoroacetic acid and 10 ml dichloromethane was stirred at room temperature over night. The reaction mixture was concentrated in vacuo.
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