7-nitro-3-(1H-pyrazol-1-yl)quinoline → 3-(1H-pyrazol-1-yl)quinolin-7-amine

HRID 2406729노트

반응식

HRID 2406729 반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([N:14]3[CH:18]=[CH:17][CH:16]=[N:15]3)[CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[N:14]1([C:9]2[CH:10]=[N:11][C:12]3[C:7]([CH:8]=2)=[CH:6][CH:5]=[C:4]([NH2:1])[CH:13]=3)[CH:18]=[CH:17][CH:16]=[N:15]1

참가 물질

4

반응물 1

HCID 686188247-nitro-3-(1H-pyrazol-1-yl)quinoline

생성물 1

HCID 866838633-(1H-pyrazol-1-yl)quinolin-7-amine수율 63.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A methanol (10 ml) solution containing 7-nitro-3-(1H-pyrazol-1-yl)quinoline (36 mg) was prepared and subjected to a hydrogenation reaction (80° C.; 50 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Thereafter, the solvent was distilled away under reduced pressure, and a purple solid of 3-(1H-pyrazol-1-yl)quinolin-7-amine (20 mg) was thus obtained.

후처리

  1. customwas prepared
  2. distillationThereafter, the solvent was distilled away under reduced pressure

출처 및 근거

ORD 기록
ord-9579e0e5a7f74c31bde648b421cbe63f
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809371B2

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